United StatesMěiguó美国scientistkēxuéjiā科学家to discoverfāxiàn发现proteindànbáizhì蛋白质FTL1 (protein)FTL1FTL1isshì是braindànǎo大脑agingshuāilǎo衰老(particle)de的key / criticalguānjiàn关键driver / driving forceqūdòng驱动factoryīnsù因素。
United States
Měiguó
美国
scientist
kēxuéjiā
科学家
to discover
fāxiàn
发现
protein
dànbáizhì
蛋白质
FTL1 (protein)
FTL1
FTL1
is
shì
是
brain
dànǎo
大脑
aging
shuāilǎo
衰老
(particle)
de
的
key / critical
guānjiàn
关键
driver / driving force
qūdòng
驱动
factor
yīnsù
因素
United States
Měiguó
美国
University of California San Francisco
Jiāzhōu Dàxué Jiùjīnshān Fēnxiào
加州大学旧金山分校
researcher
yánjiū rényuán
研究人员
in
zài
在
Nature Aging (journal)
Zìrán Shuāilǎo
《自然·衰老》
journal
qīkān
期刊
to publish
fābiǎo
发表
research / study
yánjiū
研究
to confirm
quèrèn
确认
FTL1 (protein)
FTL1
FTL1
protein
dànbáizhì
蛋白质
is
shì
是
to lead to / to cause
dǎozhì
导致
brain
dànǎo
大脑
cognitive
rènzhī
认知
function
gōngnéng
功能
along with
suí
随
age
niánlíng
年龄
to decline
xiàjiàng
下降
(particle)
de
的
core / central
héxīn
核心
factor
yīnsù
因素
research
yánjiū
研究
also
hái
还
to find
fāxiàn
发现
to reduce / to lower
jiàngdī
降低
FTL1 (protein)
FTL1
FTL1
level
shuǐpíng
水平
can
kě
可
effectively
yǒuxiào
有效
to reverse
nìzhuǎn
逆转
aged / elderly
lǎonián
老年
mouse (lab animal)
xiǎoshǔ
小鼠
(particle)
de
的
memory
jìyì
记忆
decline / deterioration
shuāituì
衰退
April 5, 2026 at 12:00 PM
United States
Měiguó
美国
UC San Francisco
Jiāzhōu Dàxué Jiùjīnshān Fēnxiào
加州大学旧金山分校
research team
yánjiū tuánduì
研究团队
recently
jìnrì
近日
in
zài
在
Nature Aging (journal)
Zìrán Shuāilǎo
《自然·衰老》
journal
qīkān
期刊
published
fābiǎo le
发表了
one / a single
yī xiàng
一项
important
zhòngyào
重要
research study
yánjiū
研究
achievement / findings
chéngguǒ
成果
researchers
yánjiū rényuán
研究人员
discovered
fāxiàn
发现
a type of
yī zhǒng
一种
named / called
míng wéi
名为
FTL1 (protein)
FTL1
FTL1
(particle)
de
的
protein
dànbáizhì
蛋白质
is
shì
是
to cause
dǎozhì
导致
brain
dànǎo
大脑
along with
suí
随
age
niánlíng
年龄
to age
shuāilǎo
衰老
cognitive
rènzhī
认知
ability / capacity
nénglì
能力
to decline
xiàjiàng
下降
(particle)
de
的
key / critical
guānjiàn
关键
driving
qūdòng
驱动
factor
yīnsù
因素
in
zài
在
aged
lǎonián
老年
mouse
xiǎoshǔ
小鼠
(particle)
de
的
hippocampus
hǎimǎtǐ
海马体
within
zhōng
中
FTL1 (protein)
FTL1
FTL1
level / content
hánliàng
含量
significantly
xiǎnzhù
显著
higher than
gāoyú
高于
young
niánqīng
年轻
mouse
xiǎoshǔ
小鼠
at the same time
tóngshí
同时
nerve cell / neuron
shénjīng xìbāo
神经细胞
between
jiān
间
(particle)
de
的
synapse
tūchù
突触
connection
liánjié
连接
also
yě
也
noticeably
míngxiǎn
明显
to decrease
jiǎnshǎo
减少
when
dāng
当
researchers
yánjiū rényuán
研究人员
artificially / deliberately
rénwéi
人为
to increase / to raise
tígāo
提高
young
niánqīng
年轻
mouse
xiǎoshǔ
小鼠
within the body
tǐnèi
体内
(particle)
de
的
FTL1 (protein)
FTL1
FTL1
level
shuǐpíng
水平
after
hòu
后
these
zhèxiē
这些
mice
xiǎoshǔ
小鼠
(particle)
de
的
brain
dànǎo
大脑
state / condition
zhuàngtài
状态
began to
kāishǐ
开始
toward
xiàng
向
aged mouse
lǎonián shǔ
老年鼠
to approach / to converge toward
kàolǒng
靠拢
more importantly
gèng zhòngyào de shì
更重要的是
to reduce
jiàngdī
降低
aged
lǎonián
老年
mouse
xiǎoshǔ
小鼠
hippocampus
hǎimǎtǐ
海马体
within
zhōng
中
FTL1 (protein)
FTL1
FTL1
(particle)
de
的
level
hánliàng
含量
after
hòu
后
their / its
qí
其
memory
jìyì
记忆
ability
nénglì
能力
showed
chūxiàn le
出现了
significant
xiǎnzhù
显著
(particle)
de
的
reversible
nìzhuǎnxìng
逆转性
improvement
gǎishàn
改善
FTL1 (protein)
FTL1
FTL1
also causes
hái huì
还会
to suppress / to inhibit
yìzhì
抑制
hippocampus
hǎimǎtǐ
海马体
cell
xìbāo
细胞
(particle)
de
的
metabolism
xīnchén dàixiè
新陈代谢
but / however
dàn
但
researchers
yánjiū rényuán
研究人员
found
fāxiàn
发现
to use
shǐyòng
使用
metabolic
dàixiè
代谢
activating
jīhuó
激活
compound
huàhéwù
化合物
can
kěyǐ
可以
effectively
yǒuxiào
有效
to block
zǔduàn
阻断
this
zhè yī
这一
effect
xiàoyìng
效应
research
yánjiū
研究
lead researcher / principal investigator
fùzérén
负责人
Villeda (researcher surname)
Wéilèdá
维勒达
professor
jiàoshòu
教授
stated
biǎoshì
表示
this
zhè yī
这一
discovery
fāxiàn
发现
for
wèi
为
to develop
kāifā
开发
targeting
zhēnduì
针对
brain
dànǎo
大脑
aging
shuāilǎo
衰老
(particle)
de
的
targeted
bǎxiàng
靶向
intervention
gānyù
干预
therapy
liáofǎ
疗法
provided
tígōng le
提供了
important
zhòngyào
重要
(particle)
de
的
scientific
kēxué
科学
foundation / basis
jīchǔ
基础
News in English
Lifestyle & CultureUCSF Scientists Identify FTL1 Protein as Key Driver of Brain Aging and Memory Decline
Researchers at UCSF published findings in Nature Aging confirming FTL1 protein as a central driver of age-related cognitive decline, with evidence that reducing FTL1 levels can reverse memory impairment in aged mice.
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