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life
shēng huó
生活
·HSK 5

scientist
kēxuéjiā
科学家
to discover / to find
fāxiàn
发现
hormone
jīsù
激素
FGF21 (fibroblast growth factor 21)
FGF21
FGF21
by means of / through
tōngguò
通过
to activate
jīhuó
激活
hindbrain (brain region)
líng nǎo
菱脑
circuit / pathway
huílù
回路
can / is able to
kě
可
to reverse
nìzhuǎn
逆转
mouse / mice (lab animal)
xiǎo shǔ
小鼠
obesity
féipàng zhèng
肥胖症
。

United States
Měiguó
美国
scientist
kēxuéjiā
科学家
to discover / to find
fāxiàn
发现
，
natural
tiānrán
天然
hormone
jīsù
激素
FGF21 (fibroblast growth factor 21)
FGF21
FGF21
can / is able to
kě
可
by means of / through
tōngguò
通过
to activate
jīhuó
激活
brain
dànǎo
大脑
hindbrain (brain region)
líng nǎo
菱脑
region / area
qūyù
区域
structural particle
de
的
specific / particular
tèdìng
特定
neural circuit
shénjīng huílù
神经回路
in order to
lái
来
to reverse
nìzhuǎn
逆转
mouse / mice (lab animal)
xiǎo shǔ
小鼠
obesity
féipàng zhèng
肥胖症
。
this / such a
zhè yī
这一
discovery / finding
fāxiàn
发现
to reveal / to uncover
jiēshì
揭示
aspect particle (completed action)
le
了
a kind of / a type of
yī zhǒng
一种
compared to / unlike
yǔ
与
GLP-1 (glucagon-like peptide-1)
GLP-1
GLP-1
type / class
lèi
类
drug / medication
yàowù
药物
fundamentally different / completely unlike
jiérán bùtóng
截然不同
structural particle
de
的
weight loss / weight reduction
jiǎn zhòng
减重
mechanism
jīzhì
机制
，
for / providing
wèi
为
new type / novel
xīn xíng
新型
obesity
féipàng
肥胖
therapy / treatment
liáofǎ
疗法
structural particle
de
的
research and development
yánfā
研发
to provide
tígōng
提供
aspect particle (completed action)
le
了
new
xīn
新
direction / avenue
fāngxiàng
方向
。

April 17, 2026 at 5:00 PM

United States
Měiguó
美国
University of Oklahoma
Ékèlāhémǎ Dàxué
俄克拉荷马大学
structural particle
de
的
researcher / research staff
yánjiū rényuán
研究人员
to discover / to find
fāxiàn
发现
，
a type of
yī zhǒng
一种
named / called
míng wéi
名为
FGF21 (fibroblast growth factor 21)
FGF21
FGF21
structural particle
de
的
natural
tiānrán
天然
hormone
jīsù
激素
can / is able to
kěyǐ
可以
by means of / through
tōngguò
通过
to activate
jīhuó
激活
brain
dànǎo
大脑
in / within
zhōng
中
structural particle
de
的
specific / particular
tèdìng
特定
neural circuit
shénjīng huílù
神经回路
in order to
lái
来
to reverse
nìzhuǎn
逆转
mouse / mice (lab animal)
xiǎo shǔ
小鼠
structural particle
de
的
obesity
féipàng zhèng
肥胖症
。
this (project / study)
zhè xiàng
这项
research / study
yánjiū
研究
in / at (a time)
yú
于
March 31
sān yuè sānshíyī rì
三月三十一日
to publish
fābiǎo
发表
in
zài
在
academic / scholarly
xuéshù
学术
journal / periodical
qīkān
期刊
Cell Reports (scientific journal)
Xìbāo Bàogào
《细胞报告》
on / in (a publication)
shàng
上
，
to reveal / to uncover
jiēshì
揭示
aspect particle (completed action)
le
了
FGF21 (fibroblast growth factor 21)
FGF21
FGF21
to regulate and control
tiáokòng
调控
metabolism
dàixiè
代谢
and
yǔ
与
body weight
tǐzhòng
体重
structural particle
de
的
entirely new / novel
quánxīn
全新
mechanism
jīzhì
机制
。
FGF21 (fibroblast growth factor 21)
FGF21
FGF21
by means of / through
tōngguò
通过
toward / to
xiàng
向
brain
dànǎo
大脑
hindbrain
líng nǎo
菱脑
region / area
qūyù
区域
to send / to transmit
fāsòng
发送
signal
xìnhào
信号
in order to
lái
来
to exert / to bring into play
fāhuī
发挥
effect / function
zuòyòng
作用
，
specifically / concretely
jùtǐ
具体
to involve / to concern
shèjí
涉及
nucleus of the solitary tract (brain structure)
gū shù hé
孤束核
and
hé
和
area postrema (brain structure)
zuìhòu qū
最后区
and / with
yǔ
与
parabrachial nucleus (brain structure)
bì páng hé
臂旁核
between
zhījiān
之间
structural particle
de
的
signal transduction
xìnhào chuándǎo
信号传导
。
unlike / compared to
yǔ
与
Ozempic (GLP-1 weight-loss drug)
Ào zé pǐ kè
奥泽匹克
and so on / such as
děng
等
GLP-1 (glucagon-like peptide-1)
GLP-1
GLP-1
type / class of
lèi
类
drug / medication
yàowù
药物
different / unlike
bùtóng
不同
，
FGF21 (fibroblast growth factor 21)
FGF21
FGF21
is not / does not
bìng fēi
并非
by means of / through
tōngguò
通过
to suppress / to inhibit
yìzhì
抑制
appetite
shíyù
食欲
to reduce / to lessen
jiǎnqīng
减轻
body weight
tǐzhòng
体重
，
but rather / instead
érshì
而是
by means of
yǐ
以
to increase / to raise
tígāo
提高
the body
shēntǐ
身体
energy expenditure
néngliàng xiāohào
能量消耗
structural particle
de
的
way / manner
fāngshì
方式
to exert / to bring into play
fāhuī
发挥
weight-loss / weight-reducing
jiǎn zhòng
减重
effect / result
xiàoguǒ
效果
。
researcher / research staff
yánjiū rényuán
研究人员
to believe / to consider
rènwéi
认为
，
this / such a
zhè yī
这一
discovery / finding
fāxiàn
发现
to contribute to / to be helpful in
yǒu zhùyú
有助于
to develop
kāifā
开发
resultative particle (producing an outcome)
chū
出
more / having greater
gèng jù
更具
targeted approach / specificity
zhēnduì xìng
针对性
、
side effect
fù zuòyòng
副作用
fewer / less
gèng shǎo
更少
structural particle
de
的
new type / novel
xīn xíng
新型
weight loss
jiǎnféi
减肥
therapy / treatment
liáofǎ
疗法
。
FGF21 (fibroblast growth factor 21)
FGF21
FGF21
analogue / similar compound
lèisì wù
类似物
already
yǐ
已
in
zài
在
clinical
línchuáng
临床
trial / experiment
shìyàn
试验
in / among
zhōng
中
used for / applied to
yòng yú
用于
to treat / treatment of
zhìliáo
治疗
metabolic dysfunction-associated steatohepatitis (MASH)
dàixiè xiāngguān zhīfáng xìng gānyán
代谢相关脂肪性肝炎
and other / such as
děng
等
related to
yǔ
与
obesity
féipàng
肥胖
closely associated / strongly linked
mìqiè xiāngguān
密切相关
structural particle
de
的
disease / illness
jíbìng
疾病
。
global / worldwide
quánqiú
全球
obesity
féipàng
肥胖
population
rénkǒu
人口
to continue / ongoing
chíxù
持续
to increase / to grow
zēngjiā
增加
，
new type / novel
xīn xíng
新型
weight-loss / weight-reducing
jiǎn zhòng
减重
mechanism
jīzhì
机制
structural particle
de
的
discovery / finding
fāxiàn
发现
for / providing
wèi
为
related / relevant
xiāngguān
相关
drug / medication
yàowù
药物
research and development
yánfā
研发
to open up / to pioneer
kāipì
开辟
aspect particle (completed action)
le
了
new
xīn
新
path / avenue
lùjìng
路径
。

New Words

Měiguó
美国
United States
Ékèlāhémǎ Dàxué
俄克拉荷马大学
University of Oklahoma
yánjiū rényuán
研究人员
researcher / research staff
fāxiàn
发现
to discover / to find
yī zhǒng
一种
a type of
míng wéi
名为
named / called
FGF21
FGF21
FGF21 (fibroblast growth factor 21)
tiānrán
天然
natural
jīsù
激素
hormone
kěyǐ
可以
can / is able to
tōngguò
通过
by means of / through
jīhuó
激活
to activate

News in English

Lifestyle & Culture

Scientists Discover Hormone FGF21 Can Reverse Obesity in Mice by Activating a Hindbrain Circuit

US scientists have found that the natural hormone FGF21 can reverse obesity in mice by activating a specific neural circuit in the hindbrain. The discovery reveals a weight-loss mechanism fundamentally different from GLP-1 drugs and opens a new avenue for obesity therapy development.

Researchers at the University of Oklahoma discovered that a natural hormone called FGF21 can reverse obesity in mice by activating specific neural circuits in the brain. This research was published on March 31 in the academic journal Cell Reports. The findings suggest potential therapeutic applications for treating human obesity. Obesity is a major health concern affecting millions of people worldwide. The researchers plan to conduct further studies to explore the hormone's effects in humans. This discovery may lead to new treatment approaches for metabolic disorders.

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