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life
shēng huó
生活
·HSK 6

phase 3 (of a clinical trial)
sān qī
三期
clinical trial
línchuáng shìyàn
临床试验
to confirm / to prove
zhèngshí
证实
new type / novel
xīn xíng
新型
antihypertensive drug
jiàngyā yào
降压药
baxdrostat (drug name)
Bā shā sī tā
巴沙司他
therapeutic efficacy
liáoxiào
疗效
significant / marked
xiǎnzhù
显著
。

to publish
fābiǎo
发表
in / at (formal)
yú
于
《
New England Journal of Medicine
Xīn Yīnggélán Yīxué Zázhì
新英格兰医学杂志
》
(relative clause marker)
de
的
phase 3
sān qī
三期
clinical trial
línchuáng shìyàn
临床试验
result
jiéguǒ
结果
to show / to indicate
xiǎnshì
显示
，
aldosterone synthase
quán gù tóng hé méi
醛固酮合酶
inhibitor
yìzhì jì
抑制剂
baxdrostat
Bā shā sī tā
巴沙司他
for / in terms of
duì
对
treatment-resistant
nán zhì xìng
难治性
hypertension / high blood pressure
gāo xuèyā
高血压
to have / to possess
jùyǒu
具有
significant / marked
xiǎnzhù
显著
therapeutic efficacy
liáoxiào
疗效
。
approximately
yuē
约
40 percent
40%
40%
(possessive particle)
de
的
medication-taking
yòng yào
用药
patient
huànzhě
患者
blood pressure
xuèyā
血压
to recover / to restore
huīfù
恢复
to / reaching (formal)
zhì
至
healthy
jiànkāng
健康
level
shuǐpíng
水平
，
US Food and Drug Administration
Měiguó Shípǐn Yàopǐn Jiāndū Guǎnlǐjú
美国食品药品监督管理局
already
yǐ
已
to accept for review
shòulǐ
受理
its (formal)
qí
其
priority review
yōuxiān shěnpíng
优先审评
application
shēnqǐng
申请
，
expected / anticipated
yùjì
预计
in (formal)
yú
于
the year 2026
2026 nián
2026年
second quarter
dì èr jìdù
第二季度
to make (a decision)
zuòchū
作出
approval
shěnpī
审批
decision
juédìng
决定
。

April 4, 2026 at 2:00 PM

the latest issue
zuì xīn yī qī
最新一期
《
New England Journal of Medicine
Xīn Yīnggélán Yīxué Zázhì
新英格兰医学杂志
》
to publish / to release
fābù
发布
(completion particle)
le
了
one (study / item)
yī xiàng
一项
about / regarding
guānyú
关于
new type / novel
xīn xíng
新型
antihypertensive drug
jiàngyā yào
降压药
baxdrostat
Bā shā sī tā
巴沙司他
（
baxdrostat (antihypertensive drug)
baxdrostat
baxdrostat
）
(relative clause marker)
de
的
phase 3
sān qī
三期
clinical trial
línchuáng shìyàn
临床试验
result
jiéguǒ
结果
。
the said / this (formal)
gāi
该
trial / experiment
shìyàn
试验
in total
gòng
共
to enroll / to include
nàrù
纳入
794 people
794 míng
794名
treatment-resistant
nán zhì xìng
难治性
or
huò
或
uncontrolled
wèi kòngzhì
未控制
hypertension
gāo xuèyā
高血压
(possessive particle)
de
的
adult
chéngnián
成年
patient
huànzhě
患者
，
random / randomized
suíjī
随机
to divide into groups
fēn zǔ
分组
to receive
jiēshòu
接受
1 milligram
1 háokè
1毫克
、
2 milligrams
2 háokè
2毫克
dosage
jìliàng
剂量
(possessive particle)
de
的
baxdrostat
Bā shā sī tā
巴沙司他
or
huò
或
placebo
ānwèi jì
安慰剂
treatment
zhìliáo
治疗
，
course of treatment
liáochéng
疗程
12 weeks
shí èr zhōu
十二周
。
result
jiéguǒ
结果
to show / to indicate
xiǎnshì
显示
，
to take (medicine)
fúyòng
服用
1 milligram
1 háokè
1毫克
dosage
jìliàng
剂量
(possessive particle)
de
的
patient
huànzhě
患者
systolic blood pressure
shōusuō yā
收缩压
average / on average
píngjūn
平均
to decrease / to drop
xiàjiàng
下降
14.5 mmHg
14.5 háomǐ gǒngzhù
14.5毫米汞柱
，
to take (medicine)
fúyòng
服用
2 milligrams
2 háokè
2毫克
(possessive particle)
de
的
patient
huànzhě
患者
to decrease / to drop
xiàjiàng
下降
15.7 mmHg
15.7 háomǐ gǒngzhù
15.7毫米汞柱
，
both / all (formal)
jūn
均
significantly
xiǎnzhù
显著
superior to / better than
yōu yú
优于
placebo
ānwèi jì
安慰剂
group
zǔ
组
(possessive particle)
de
的
5.8 mmHg
5.8 háomǐ gǒngzhù
5.8毫米汞柱
。
even more / particularly (formal)
gèng wéi
更为
key / critical
guānjiàn
关键
(possessive particle)
de
的
is
shì
是
，
approximately
yuē
约
40 percent
40%
40%
(possessive particle)
de
的
medication-taking
yòng yào
用药
patient
huànzhě
患者
blood pressure
xuèyā
血压
to recover / to restore
huīfù
恢复
to / reaching (formal)
zhì
至
healthy
jiànkāng
健康
level
shuǐpíng
水平
，
far / much
yuǎn
远
higher than
gāo yú
高于
placebo
ānwèi jì
安慰剂
group
zǔ
组
less than / insufficient
bùzú
不足
20 percent
20%
20%
(possessive particle)
de
的
proportion / ratio
bǐlì
比例
。
baxdrostat
Bā shā sī tā
巴沙司他
is
shì
是
a type of
yī zhǒng
一种
aldosterone synthase
quán gù tóng hé méi
醛固酮合酶
inhibitor
yìzhì jì
抑制剂
，
through / by means of
tōngguò
通过
to inhibit / to suppress
yìzhì
抑制
adrenal gland
shèn shàng xiàn
肾上腺
to secrete
fēnmì
分泌
aldosterone
quán gù tóng
醛固酮
hormone
jīsù
激素
to (purpose marker)
lái
来
to lower / to reduce
jiàngdī
降低
blood pressure
xuèyā
血压
，
its (formal)
qí
其
mechanism of action
zuòyòng jīzhì
作用机制
with / compared with
yǔ
与
existing / current
xiàn yǒu
现有
first-line (treatment)
yī xiàn
一线
antihypertensive drug
jiàngyā yào
降压药
completely different / diametrically opposite
jié rán bù tóng
截然不同
。
researchers
yánjiū rényuán
研究人员
to point out
zhǐchū
指出
，
this (formal)
zhè yī
这一
drug target
bǎ diǎn
靶点
for / in terms of
duì
对
aldosterone
quán gù tóng
醛固酮
to secrete
fēnmì
分泌
excessive / too much
guò duō
过多
caused by (formal)
suǒ zhì
所致
hypertension
gāo xuèyā
高血压
patient
huànzhě
患者
particularly / especially (formal)
yóuwéi
尤为
effective
yǒuxiào
有效
，
while / and (formal)
ér
而
such type / this kind (formal)
cǐ lèi
此类
patient
huànzhě
患者
in / among
zài
在
treatment-resistant
nán zhì xìng
难治性
hypertension
gāo xuèyā
高血压
population / group
qúntǐ
群体
within / among
zhōng
中
to account for / to make up
zhàn
占
considerable / significant
xiāngdāng
相当
proportion
bǐlì
比例
。
in / regarding
zài
在
safety (as a quality)
ānquán xìng
安全性
aspect / regard
fāngmiàn
方面
，
a small number / minority
shǎoshù
少数
study participant / test subject
shòushì zhě
受试者
to develop / to experience
chūxiàn
出现
hyperkalemia (high blood potassium)
gāo jiǎ xuè zhèng
高钾血症
，
to need / must (formal)
xū
需
in
zài
在
clinical
línchuáng
临床
practice / application
shíjiàn
实践
within
zhōng
中
to apply / to subject to (formal)
jiāyǐ
加以
monitoring / to monitor
jiāncè
监测
。
US Food and Drug Administration
Měiguó Shípǐn Yàopǐn Jiāndū Guǎnlǐjú
美国食品药品监督管理局
already
yǐ
已
(action marker)
jiāng
将
the drug / this drug
gāi yào
该药
to include / to place on list
lièrù
列入
priority review
yōuxiān shěnpíng
优先审评
program / procedure
chéngxù
程序
，
target
mùbiāo
目标
approval
shěnpī
审批
date
rìqī
日期
set for / scheduled for
dìng yú
定于
the year 2026
2026 nián
2026年
second quarter
dì èr jìdù
第二季度
。
given that / in light of (formal)
jiànyú
鉴于
global
quánqiú
全球
hypertension
gāo xuèyā
高血压
patient
huànzhě
患者
total number
zǒngshù
总数
more than / exceeding (formal)
yú
逾
one billion people
shí yì rén
十亿人
，
among which / of which
qízhōng
其中
treatment-resistant
nán zhì xìng
难治性
case (medical)
bìnglì
病例
proportion
bǐlì
比例
considerable / significant
kěguān
可观
，
this (occasion / trial)
cǐ cì
此次
trial
shìyàn
试验
result
jiéguǒ
结果
(passive marker)
bèi
被
medical community / medical circles
yīxué jiè
医学界
to regard as / to consider as
shì wéi
视为
important / significant
zhòngyào
重要
breakthrough
tūpò
突破
。

News in English

Lifestyle & Culture

Phase 3 Trial Shows Baxdrostat Significantly Lowers Blood Pressure in Patients Resistant to Standard Treatment

A phase 3 clinical trial in the New England Journal of Medicine shows baxdrostat, an aldosterone synthase inhibitor, significantly lowers blood pressure in resistant hypertension patients, with around 40 percent reaching healthy levels.

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to advance into / to push forward to
tǐnɡjìn
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Ōuɡuàn
欧冠
final / championship match
juésài
决赛
，
to face / to compete against
duìzhèn
对阵
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tàikōng wàngyuǎnjìng
太空望远镜
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fāshè
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tíqián zhì
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2026 nián 9 yuè
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Déyuē Kēwéiqí
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jìnjí
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Fǎwǎng
法网
third round
dì sān lún
第三轮
，
will
jiāng
将
to face / to take on (in competition)
yíngzhàn
迎战
19-year-old
19 suì
19岁
structural particle
de
的
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temperature / air temperature
qìwēn
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liánxù
连续
two days
liǎng tiān
两天
to break (a record)
pò
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historical record
lìshǐ jìlù
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。

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