researchers / scientistsyánjiū rényuán研究人员for the first timeshǒucì首次inzài在laboratoryshíyàn shì实验室grew / developedpéiyù chū培育出esophagus / food pipeshí guǎn食管replacement / substitutetìdài wù替代物,transplantedyízhí移植afterhòu后animaldòngwù动物eating / swallowingjìn shí进食functiongōngnéng功能restoredhuīfù恢复normalzhèngcháng正常。
researchers / scientists
yánjiū rényuán
研究人员
for the first time
shǒucì
首次
in
zài
在
laboratory
shíyàn shì
实验室
grew / developed
péiyù chū
培育出
esophagus / food pipe
shí guǎn
食管
replacement / substitute
tìdài wù
替代物
transplanted
yízhí
移植
after
hòu
后
animal
dòngwù
动物
eating / swallowing
jìn shí
进食
function
gōngnéng
功能
restored
huīfù
恢复
normal
zhèngcháng
正常
United Kingdom
Yīngguó
英国
two (institutions)
liǎng suǒ
两所
top-tier / leading
dǐngjiān
顶尖
hospitals
yīyuàn
医院
structural particle
de
的
researchers / scientists
kēyán rényuán
科研人员
successfully
chénggōng
成功
in
zài
在
laboratory
shíyàn shì
实验室
grew / developed
péiyù chū
培育出
esophagus / food pipe
shí guǎn
食管
replacement / substitute
tìdài wù
替代物
and / moreover
bìng
并
it
jiāng qí
将其
transplanted
yízhí
移植
into / to
dào
到
pig
zhū
猪
inside the body
tǐ nèi
体内
restored
huīfù le
恢复了
normal
zhèngcháng
正常
eating / swallowing
jìn shí
进食
function
gōngnéng
功能
the / this
gāi
该
study / research
yánjiū
研究
without the need for
wú xū
无需
immunosuppressants
miǎnyì yìzhì jì
免疫抑制剂
experimental animals
shíyàn dòngwù
实验动物
all
jūn
均
successfully
chénggōng
成功
survived
cúnhuó
存活
the research team
xiāngguān tuánduì
相关团队
hopes
xīwàng
希望
within five years
wǔ nián nèi
五年内
for
wèi
为
child patients
huàn ér
患儿
to provide / offer
tígōng
提供
this
zhè yī
这一
alternative solution / replacement option
tìdài fāng àn
替代方案
March 24, 2026 at 2:00 PM
United Kingdom
Yīngguó
英国
Great Ormond Street
Dà Àomèngdé Jiē
大奥蒙德街
children hospital
ér tóng yīyuàn
儿童医院
and / with
yǔ
与
University College London (UCL)
Lúndūn Dàxué Xuéyuàn
伦敦大学学院
structural particle
de
的
research team
kēyán tuánduì
科研团队
in / during
yú
于
March 2026
2026 nián 3 yuè
2026年3月
to release / publish
fābù
发布
research findings / results
yánjiū chéngguǒ
研究成果
demonstrated / showed
zhǎnshì le
展示了
world
shìjiè
世界
first
shǒu gè
首个
laboratory
shíyàn shì
实验室
lab-grown / cultivated
péiyù de
培育的
esophagus / food pipe
shí guǎn
食管
replacement / substitute
tìdài wù
替代物
researchers
yánjiū rényuán
研究人员
through / by means of
tōngguò
通过
decellularization / cell-stripping process
tuō xìbāo huà
脱细胞化
technology / technique
jìshù
技术
to
jiāng
将
donor pig
juānxiàn zhū
捐献猪
structural particle
de
的
esophagus
shí guǎn
食管
to process into
chǔlǐ chéng
处理成
cellular scaffold / tissue scaffold
xìbāo zhī jià
细胞支架
then / subsequently
zài
再
to inject
zhùrù
注入
recipient
shòutǐ
受体
pig
zhū
猪
own / self
zìshēn
自身
structural particle
de
的
muscle cells
jīròu xìbāo
肌肉细胞
and / moreover
bìng
并
in
zài
在
in vitro / outside the body
tǐ wài
体外
in large quantities
dàliàng
大量
to culture / cultivate
péiyǎng
培养
containing
hányǒu
含有
recipient cells
shòutǐ xìbāo
受体细胞
structural particle
de
的
esophagus
shí guǎn
食管
replacement
tìdài wù
替代物
subsequently / then
suíhòu
随后
was (passive marker)
bèi
被
transplanted
yízhí
移植
into
dào
到
eight
bā zhī
八只
living pigs
huótǐ zhū
活体猪
on / in their bodies
shēn shàng
身上
all
suǒyǒu
所有
animals
dòngwù
动物
all
jūn
均
successfully
chénggōng
成功
survived / passed through
dùguò le
度过了
post-operative / after surgery
shù hòu
术后
the first month
shǒu gè yuè
首个月
structural particle
de
的
critical period
guānjiàn qī
关键期
by / until
zhì
至
six months
liù gè yuè
六个月
observation period
guānchá qī
观察期
at the end of
jiéshù shí
结束时
transplanted
yízhí de
移植的
esophagus
shí guǎn
食管
already / had
yǐ
已
developed
fāyù chū
发育出
functional
gōngnéng xìng
功能性
muscle
jīròu
肌肉
nerves
shénjīng
神经
and / as well as
jí
及
blood vessels
xuèguǎn
血管
able to / can
nénggòu
能够
normal
zhèngcháng
正常
to contract
shōusuō
收缩
to transmit / pass along
chuándì
传递
food
shíwù
食物
compared to / unlike
yǔ
与
traditional / conventional
chuántǒng
传统
organ transplant
qìguān yízhí
器官移植
different / unlike
bùtóng
不同
the entire process
zhěnggè guòchéng
整个过程
without the need for
wú xū
无需
using
shǐyòng
使用
immunosuppressants
miǎnyì yìzhì jì
免疫抑制剂
significantly
dàfú
大幅
reduced
jiàngdī le
降低了
transplant
yízhí
移植
risk
fēngxiǎn
风险
and / as well as
jí
及
long-term
cháng qī
长期
side effects
fù zuòyòng
副作用
principal investigator / lead researcher
shǒuxí yánjiūyuán
首席研究员
de Coppi (surname)
Dé Kē pí
德科皮
Professor
jiàoshòu
教授
stated / said
biǎoshì
表示
team
tuánduì
团队
hopes
xīwàng
希望
in / within
zài
在
within five years
wǔ nián nèi
五年内
for
wèi
为
congenital / born with
xiāntiān xìng
先天性
esophagus
shí guǎn
食管
underdevelopment / incomplete development
fāyù bù quán
发育不全
structural particle
de
的
child patients
huàn ér
患儿
to provide / offer
tígōng
提供
engineered / bioengineered
gōngchéng huà
工程化
esophagus
shí guǎn
食管
alternative solution / replacement option
tìdài fāng àn
替代方案
congenital esophageal atresia
xiāntiān xìng shí guǎn bì suǒ
先天性食管闭锁
is
shì
是
at birth
chūshēng shí
出生时
esophagus
shí guǎn
食管
partly / partially
bùfen
部分
missing / absent
quēshī
缺失
structural particle
de
的
rare disease
hǎnjiàn bìng
罕见病
this
cǐ cì
此次
breakthrough
tūpò
突破
for
wèi
为
child patients
huàn ér
患儿
brought
dài lái le
带来了
important
zhòngyào de
重要的
treatment
zhìliáo
治疗
hope
xīwàng
希望
News in English
Lifestyle & CultureUK Scientists Grow World First Lab-Made Esophagus and Successfully Transplant It in Pigs
UK researchers at Great Ormond Street Hospital and University College London successfully grew the first lab-made esophagus and transplanted it in pigs, restoring normal swallowing function without immunosuppressants. The research team hopes to offer the engineered tissue to child patients within five years.
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